The wonder of longevity is muted by the pain and cost of aging disease. More than five million Americans have Alzheimer's, and that number will multiply as the nation's demographic shift accelerates. Without prevention, treatment and cure, Alzheimer's looms as a trillion dollar threat that can overwhelm us. It will take a movement - commitment, resources, focus and a wave of innovative thinking to curb this threat. What is the state of play? The promises? The failures? The impediments? What new research paths are being traveled? What policies must be pursued? And what of the other diseases of aging, such as diabetes? Are we making the progress that's needed? How will scientific advances help us realize the potential of longevity?