In the 1990s, it was estimated that sequencing a single human genome would cost $3 billion and take more than a decade. The cost of mapping an individual human genome may break the $1,000 barrier by the end of the year. This opens up the ability to deliver the right medicine to the right patient at the right time. Panelists will analyze the mysteries of the human genome and practical ways to use this information. How can clinicians reinvent the way they evaluate signs and symptoms of disease and instead base diagnosis on underlying molecular causes? How do we ensure the scientific trajectory toward more personalized treatments will not be squelched by the countervailing pressure to pay only for treatments deemed most effective in large populations of patients?