Philanthropic investment accounts for 3 percent of overall medical research spending, but plays an outsized role by fostering innovative R&D models that can accelerate the development of life-saving therapies. These investments can catalyze high-risk research too often abandoned by government and industry, stimulate fruitful collaborations among nontraditional allies, and refocus a research field on unmet patient needs. Hear from venture philanthropists who are using their passion capital and private sector savvy to redefine the medical research status quo and realize research progress for patients in their lifetime.